4XTU

Mycobacterium tuberculosis biotin ligase complexed with bisubstrate inhibitor (N-({[(1R,2S,3R,4R)-4-(6-amino-9H-purin-9-yl)-2,3-dihydroxycyclopentyl]methyl}sulfamoyl)-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide)

Summary for 4XTU

• Entry DOI: 10.2210/pdb4xtu/pdb
• Related: 4XTV 4XTW 4XTX 4XTY 4XTZ 4XU0 4XU1 4XU2 4XU3
• Descriptor: Bifunctional ligase/repressor BirA, N-({[(1R,2S,3R,4R)-4-(6-amino-9H-purin-9-yl)-2,3-dihydroxycyclopentyl]methyl}sulfamoyl)-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide (3 entities in total)
• Functional Keywords: biotin-protein ligase, bisubstrate inhibitor, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• Biological source: Mycobacterium tuberculosis
• Total number of polymer chains: 2
• Total formula weight: 58208.17

Authors

De la Mora-Rey, T.,Finzel, B.C. (deposition date: 2015-01-24, release date: 2016-01-13, Last modification date: 2023-09-27)

• Primary citation: Bockman, M.R.,Kalinda, A.S.,Petrelli, R.,De la Mora-Rey, T.,Tawari, D.,Liu, F.,Schnappinger, D.,Finzel, B.C.,Aldrich, C.C.; Mycobacterium tuberculosis biotin ligase complexed with bisubstrate inhibitor (N-({[(1R,2S,3R,4R)-4-(6-amino-9H-purin-9-yl)-2,3-dihydroxycyclopentyl]methyl}sulfamoyl)-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide); To be Published,

Experimental method

X-RAY DIFFRACTION (1.65002988236 Å)