4XRM
homodimer of TALE type homeobox transcription factor MEIS1 complexes with specific DNA
Summary for 4XRM
Entry DOI | 10.2210/pdb4xrm/pdb |
Descriptor | DNA (5'-D(P*AP*GP*CP*TP*GP*AP*CP*AP*GP*CP*TP*GP*TP*CP*AP*AP*G)-3'), DNA (5'-D(P*TP*CP*TP*TP*GP*AP*CP*AP*GP*CP*TP*GP*TP*CP*AP*GP*C)-3'), Homeobox protein Meis2, ... (5 entities in total) |
Functional Keywords | tale homeobox, meis, complex, dna, transcription |
Biological source | Homo sapiens (Human) More |
Cellular location | Nucleus : O14770 |
Total number of polymer chains | 4 |
Total formula weight | 25694.44 |
Authors | Morgunova, E.,Jorma, A.,Yin, Y.,Nitta, K.R.,Dave, K.,Enge, M.,Kivioja, T.,Popov, A.,Taipale, J. (deposition date: 2015-01-21, release date: 2015-11-04, Last modification date: 2024-01-10) |
Primary citation | Jolma, A.,Yin, Y.,Nitta, K.R.,Dave, K.,Popov, A.,Taipale, M.,Enge, M.,Kivioja, T.,Morgunova, E.,Taipale, J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature, 527:384-388, 2015 Cited by PubMed: 26550823DOI: 10.1038/nature15518 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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