4XO7

Crystal structure of human 3-alpha hydroxysteroid dehydrogenase type 3 in complex with NADP+, 5alpha-androstan-3,17-dione and (3beta, 5alpha)-3-hydroxyandrostan-17-one

Summary for 4XO7

• Entry DOI: 10.2210/pdb4xo7/pdb
• Related: 4L1W 4NNF 4XO6
• Descriptor: Aldo-keto reductase family 1 member C2, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 4-ANDROSTENE-3-17-DIONE, ... (5 entities in total)
• Functional Keywords: alpha-beta barrel, human 3-alpha hds3, akr, akr1c2, aldo-keto reductase, nadph, oxidoreductase
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm : P52895
• Total number of polymer chains: 2
• Total formula weight: 75824.29

Authors

Zhang, B.,Hu, X.-J.,Lin, S.-X. (deposition date: 2015-01-16, release date: 2016-02-17, Last modification date: 2024-02-28)

• Primary citation: Zhang, B.,Hu, X.J.,Wang, X.Q.,Theriault, J.F.,Zhu, D.W.,Shang, P.,Labrie, F.,Lin, S.X.; Human 3 alpha-hydroxysteroid dehydrogenase type 3: structural clues of 5 alpha-DHT reverse binding and enzyme down-regulation decreasing MCF7 cell growth.; Biochem.J., 473:1037-1046, 2016; PubMed: 26929402; DOI: 10.1042/BCJ20160083

Experimental method

X-RAY DIFFRACTION (1.75 Å)