4XO7
Crystal structure of human 3-alpha hydroxysteroid dehydrogenase type 3 in complex with NADP+, 5alpha-androstan-3,17-dione and (3beta, 5alpha)-3-hydroxyandrostan-17-one
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Aldo-keto reductase family 1 member C2 | polymer | 323 | 36786.3 | 2 | UniProt (P52895) Pfam (PF00248) | Homo sapiens (Human) | 3-alpha-HSD3,Chlordecone reductase homolog HAKRD,Dihydrodiol dehydrogenase 2,DD2,Dihydrodiol dehydrogenase/bile acid-binding protein,DD/BABP,Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase,Type III 3-alpha-hydroxysteroid dehydrogenase |
| 2 | C, F (A, B) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 2 | Chemie (NAP) | |||
| 3 | D, G (A, B) | 4-ANDROSTENE-3-17-DIONE | non-polymer | 286.4 | 2 | Chemie (ASD) | |||
| 4 | E, H (A, B) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 5 | I, J (A, B) | water | water | 18.0 | 335 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 73572.5 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 2251.8 | |
| All* | Total formula weight | 75824.3 |
