4XO7
Crystal structure of human 3-alpha hydroxysteroid dehydrogenase type 3 in complex with NADP+, 5alpha-androstan-3,17-dione and (3beta, 5alpha)-3-hydroxyandrostan-17-one
Summary for 4XO7
Entry DOI | 10.2210/pdb4xo7/pdb |
Related | 4L1W 4NNF 4XO6 |
Descriptor | Aldo-keto reductase family 1 member C2, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 4-ANDROSTENE-3-17-DIONE, ... (5 entities in total) |
Functional Keywords | alpha-beta barrel, human 3-alpha hds3, akr, akr1c2, aldo-keto reductase, nadph, oxidoreductase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : P52895 |
Total number of polymer chains | 2 |
Total formula weight | 75824.29 |
Authors | Zhang, B.,Hu, X.-J.,Lin, S.-X. (deposition date: 2015-01-16, release date: 2016-02-17, Last modification date: 2024-02-28) |
Primary citation | Zhang, B.,Hu, X.J.,Wang, X.Q.,Theriault, J.F.,Zhu, D.W.,Shang, P.,Labrie, F.,Lin, S.X. Human 3 alpha-hydroxysteroid dehydrogenase type 3: structural clues of 5 alpha-DHT reverse binding and enzyme down-regulation decreasing MCF7 cell growth. Biochem.J., 473:1037-1046, 2016 Cited by PubMed: 26929402DOI: 10.1042/BCJ20160083 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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