4XO6

Crystal structure of human 3-alpha hydroxysteroid dehydrogenase type 3 in complex with NADP+, 5alpha-androstan-3,17-dione and (3beta, 5alpha)-3-hydroxyandrostan-17-one

4XO6 の概要

• エントリーDOI: 10.2210/pdb4xo6/pdb
• 関連するPDBエントリー: 4L1W 4L1X 4XO7
• 分子名称: Aldo-keto reductase family 1 member C2, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5ALPHA-ANDROSTAN-3,17-DIONE, ... (8 entities in total)
• 機能のキーワード: alpha-beta barrel, human 3-alpha hds3, akr, akr1c2, aldo-keto reductase, nadph, oxidoreductase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 76386.76

構造登録者

Zhang, B.,Hu, X.-J.,Lin, S.-X. (登録日: 2015-01-16, 公開日: 2016-02-17, 最終更新日: 2024-02-28)

• 主引用文献: Zhang, B.,Hu, X.J.,Wang, X.Q.,Theriault, J.F.,Zhu, D.W.,Shang, P.,Labrie, F.,Lin, S.X.; Human 3 alpha-hydroxysteroid dehydrogenase type 3: structural clues of 5 alpha-DHT reverse binding and enzyme down-regulation decreasing MCF7 cell growth.; Biochem.J., 473:1037-1046, 2016; PubMed: 26929402; DOI: 10.1042/BCJ20160083

実験手法

X-RAY DIFFRACTION (1.2 Å)