4XO6
Crystal structure of human 3-alpha hydroxysteroid dehydrogenase type 3 in complex with NADP+, 5alpha-androstan-3,17-dione and (3beta, 5alpha)-3-hydroxyandrostan-17-one
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Aldo-keto reductase family 1 member C2 | polymer | 325 | 36956.4 | 2 | UniProt (P52895) Pfam (PF00248) In PDB | Homo sapiens (Human) | 3-alpha-HSD3,Chlordecone reductase homolog HAKRD,Dihydrodiol dehydrogenase 2,DD2,Dihydrodiol dehydrogenase/bile acid-binding protein,DD/BABP,Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase,Type III 3-alpha-hydroxysteroid dehydrogenase |
| 2 | A, B | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 2 | Chemie (NAP) | |||
| 3 | A | 5ALPHA-ANDROSTAN-3,17-DIONE | non-polymer | 288.4 | 1 | Chemie (5SD) | |||
| 4 | A, B | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 5 | A, B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 6 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 7 | B | (3Beta,5alpha)-3-Hydroxyandrostan-17-one | non-polymer | 290.4 | 1 | Chemie (AOX) | |||
| 8 | water | water | 18.0 | 832 | Chemie (HOH) |
Sequence modifications
A, B: 2 - 323 (UniProt: P52895)
| PDB | External Database | Details |
|---|---|---|
| Ser -1 | - | expression tag |
| Val 0 | - | expression tag |
| Asp 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 73912.7 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 2474.0 | |
| All* | Total formula weight | 76386.8 |
