4XNU

X-ray structure of Drosophila dopamine transporter in complex with nisoxetine

4XNU の概要

• エントリーDOI: 10.2210/pdb4xnu/pdb
• 関連するPDBエントリー: 4M48 4XNX
• 分子名称: Integral membrane protein-dopamine transporter, antibody fragment light chain, antibody fragment heavy chain, ... (8 entities in total)
• 機能のキーワード: integral membrane protein, all-alpha helical antidepressant complex, transport protein-inhibitor complex, transport protein/inhibitor
• 由来する生物種: Drosophila melanogaster; 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 109651.42

構造登録者

Aravind, P.,Wang, K.,Gouaux, E. (登録日: 2015-01-16, 公開日: 2015-05-13, 最終更新日: 2024-10-16)

主引用文献

Penmatsa, A.,Wang, K.H.,Gouaux, E.
X-ray structures of Drosophila dopamine transporter in complex with nisoxetine and reboxetine.
Nat.Struct.Mol.Biol., 22:506-508, 2015

PubMed Abstract: Most antidepressants elicit their therapeutic benefits through selective blockade of Na(+)/Cl(-)-coupled neurotransmitter transporters. Here we report X-ray structures of the Drosophila melanogaster dopamine transporter in complexes with the polycyclic antidepressants nisoxetine or reboxetine. The inhibitors stabilize the transporter in an outward-open conformation by occupying the substrate-binding site. These structures explain how interactions between the binding pocket and substituents on the aromatic rings of antidepressants modulate drug-transporter selectivity.

PubMed: 25961798
DOI: 10.1038/nsmb.3029

実験手法

X-RAY DIFFRACTION (2.98 Å)