4XMI

Crystal structure of the K499G mutant of NanB sialidase from Streptococcus pneumoniae

Summary for 4XMI

• Entry DOI: 10.2210/pdb4xmi/pdb
• Descriptor: Sialidase B, DIMETHYL SULFOXIDE, PHOSPHATE ION, ... (4 entities in total)
• Functional Keywords: hydrolase, intramolecular trans-sialidase, glycosidase, drug design, neuraminidase, allosteric inhibitor, serendipitous allosteric sites, crystallization artefacts
• Biological source: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
• Total number of polymer chains: 1
• Total formula weight: 74011.49

Authors

Brear, P. (deposition date: 2015-01-14, release date: 2016-01-13, Last modification date: 2024-01-10)

• Primary citation: Rogers, G.W.,Brear, P.,Yang, L.,Chen, A.S.,Mitchell, J.B.O.,Taylor, G.L.,Westwood, N.J.; The Hunt for Serendipitous Allosteric Sites: Discovery of a novel allosteric inhibitor of the bacterial sialidase NanB; To be published,

Experimental method

X-RAY DIFFRACTION (1.97 Å)