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4XIK

Crystal structure of NanB sialidase from streptococcus pneumoniae in complex with DMSO

Summary for 4XIK
Entry DOI10.2210/pdb4xik/pdb
DescriptorSialidase B, DIMETHYL SULFOXIDE (3 entities in total)
Functional Keywordshydrolase, intramolecular trans-sialidase, glycosidase, drug design, neuraminidase, allosteric inhibitor, serendipitous allosteric sites, crystallization artefacts
Biological sourceStreptococcus pneumoniae TIGR4
Total number of polymer chains1
Total formula weight73910.52
Authors
Brear, P. (deposition date: 2015-01-07, release date: 2016-01-20, Last modification date: 2024-01-10)
Primary citationRogers, G.W.,Brear, P.,Yang, L.,Chen, A.S.,Mitchell, J.B.O.,Taylor, G.L.,Westwood, N.J.
`The Hunt for Serendipitous Allosteric Sites: Discovery of a novel allosteric inhibitor of the bacterial sialidase NanB
To be published,
Experimental method
X-RAY DIFFRACTION (1.91 Å)
Structure validation

218500

數據於2024-04-17公開中

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