4XH9

CRYSTAL STRUCTURE OF HUMAN RHOA IN COMPLEX WITH DH/PH FRAGMENT OF THE GUANINE NUCLEOTIDE EXCHANGE FACTOR NET1

4XH9 の概要

• エントリーDOI: 10.2210/pdb4xh9/pdb
• 分子名称: Neuroepithelial cell-transforming gene 1 protein, Transforming protein RhoA (3 entities in total)
• 機能のキーワード: rhoa gtpase, signaling protein, activator, guanine nucleotide exchange factor
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 125043.09

構造登録者

Garcia, C.,Petit, P.,Boutin, J.A.,Ferry, G.,Vuillard, L. (登録日: 2015-01-05, 公開日: 2015-01-14, 最終更新日: 2024-01-10)

• 主引用文献: Petit, A.P.,Garcia-Petit, C.,Bueren-Calabuig, J.A.,Vuillard, L.M.,Ferry, G.,Boutin, J.A.; A structural study of the complex between neuroepithelial cell transforming gene 1 (Net1) and RhoA reveals a potential anticancer drug hot spot.; J. Biol. Chem., 293:9064-9077, 2018; PubMed: 29695506; DOI: 10.1074/jbc.RA117.001123

実験手法

X-RAY DIFFRACTION (2 Å)