4XAS

mGluR2 ECD ligand complex

Summary for 4XAS

• Entry DOI: 10.2210/pdb4xas/pdb
• Related: 4XAQ 4XAR
• Descriptor: Metabotropic glutamate receptor 2, (1R,4S,5S,6S)-4-aminospiro[bicyclo[3.1.0]hexane-2,1'-cyclopropane]-4,6-dicarboxylic acid (3 entities in total)
• Functional Keywords: mglur2 ecd, signaling protein
• Biological source: Homo sapiens (Human)
• Cellular location: Cell membrane; Multi-pass membrane protein: Q14416
• Total number of polymer chains: 2
• Total formula weight: 111848.09

Authors

Clawson, D.K. (deposition date: 2014-12-15, release date: 2015-02-04, Last modification date: 2017-11-22)

• Primary citation: Monn, J.A.,Prieto, L.,Taboada, L.,Pedregal, C.,Hao, J.,Reinhard, M.R.,Henry, S.S.,Goldsmith, P.J.,Beadle, C.D.,Walton, L.,Man, T.,Rudyk, H.,Clark, B.,Tupper, D.,Baker, S.R.,Lamas, C.,Montero, C.,Marcos, A.,Blanco, J.,Bures, M.,Clawson, D.K.,Atwell, S.,Lu, F.,Wang, J.,Russell, M.,Heinz, B.A.,Wang, X.,Carter, J.H.,Xiang, C.,Catlow, J.T.,Swanson, S.,Sanger, H.,Broad, L.M.,Johnson, M.P.,Knopp, K.L.,Simmons, R.M.,Johnson, B.G.,Shaw, D.B.,McKinzie, D.L.; Synthesis and Pharmacological Characterization of C4-Disubstituted Analogs of 1S,2S,5R,6S-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: Identification of a Potent, Selective Metabotropic Glutamate Receptor Agonist and Determination of Agonist-Bound Human mGlu2 and mGlu3 Amino Terminal Domain Structures.; J.Med.Chem., 58:1776-1794, 2015; PubMed: 25602126; DOI: 10.1021/jm501612y

Experimental method

X-RAY DIFFRACTION (2.35 Å)