4X7Z

MycF mycinamicin III 3'-O-methyltransferase (E35Q, M56A, E139A variant) in complex with Mg, SAH and mycinamicin III (substrate)

4X7Z の概要

• エントリーDOI: 10.2210/pdb4x7z/pdb
• 関連するPDBエントリー: 4X7U 4X7V 4X7W 4X7X 4X7Y 4X81
• 分子名称: Mycinamicin III 3''-O-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, MAGNESIUM ION, ... (6 entities in total)
• 機能のキーワード: macrolide, methyltransferase, antibiotic, natural product, transferase-antibiotic complex, transferase/antibiotic
• 由来する生物種: Micromonospora griseorubida
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 63805.17

構造登録者

Bernard, S.M.,Smith, J.L. (登録日: 2014-12-09, 公開日: 2015-03-04, 最終更新日: 2024-02-28)

• 主引用文献: Bernard, S.M.,Akey, D.L.,Tripathi, A.,Park, S.R.,Konwerski, J.R.,Anzai, Y.,Li, S.,Kato, F.,Sherman, D.H.,Smith, J.L.; Structural Basis of Substrate Specificity and Regiochemistry in the MycF/TylF Family of Sugar O-Methyltransferases.; Acs Chem.Biol., 10:1340-1351, 2015; PubMed: 25692963; DOI: 10.1021/cb5009348

実験手法

X-RAY DIFFRACTION (1.44 Å)