4X7U

MycF mycinamicin III 3'-O-methyltransferase in complex with Mg, SAH and mycinamicin III (substrate)

Summary for 4X7U

Entry DOI	10.2210/pdb4x7u/pdb
Related	4X7V 4X7W 4X7X 4X7Y 4X7Z 4X81
Descriptor	Mycinamicin III 3''-O-methyltransferase, MAGNESIUM ION, S-ADENOSYL-L-HOMOCYSTEINE, ... (5 entities in total)
Functional Keywords	macrolide, methyltransferase, antibiotic, natural product, transferase-antibiotic complex, transferase/antibiotic
Biological source	Micromonospora griseorubida
Total number of polymer chains	2
Total formula weight	63814.26
Authors	Bernard, S.M.,Smith, J.L. (deposition date: 2014-12-09, release date: 2015-03-04, Last modification date: 2023-09-27)
Primary citation	Bernard, S.M.,Akey, D.L.,Tripathi, A.,Park, S.R.,Konwerski, J.R.,Anzai, Y.,Li, S.,Kato, F.,Sherman, D.H.,Smith, J.L. Structural Basis of Substrate Specificity and Regiochemistry in the MycF/TylF Family of Sugar O-Methyltransferases. Acs Chem.Biol., 10:1340-1351, 2015 Cited by PubMed: 25692963 DOI: 10.1021/cb5009348 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation