4X7Q

PIM2 kinase in complex with Compound 1s

4X7Q の概要

• エントリーDOI: 10.2210/pdb4x7q/pdb
• 分子名称: Serine/threonine-protein kinase pim-2, 2-(2,6-difluorophenyl)-N-{4-[(3S)-pyrrolidin-3-yloxy]pyridin-3-yl}-1,3-thiazole-4-carboxamide, PHOSPHATE ION, ... (4 entities in total)
• 機能のキーワード: transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 69532.56

構造登録者

Marcotte, D.J.,Silvian, L.F. (登録日: 2014-12-09, 公開日: 2015-02-11, 最終更新日: 2023-09-27)

• 主引用文献: Ishchenko, A.,Zhang, L.,Le Brazidec, J.Y.,Fan, J.,Chong, J.H.,Hingway, A.,Raditsis, A.,Singh, L.,Elenbaas, B.,Hong, V.S.,Marcotte, D.,Silvian, L.,Enyedy, I.,Chao, J.; Structure-based design of low-nanomolar PIM kinase inhibitors.; Bioorg.Med.Chem.Lett., 25:474-480, 2015; PubMed: 25575657; DOI: 10.1016/j.bmcl.2014.12.041

実験手法

X-RAY DIFFRACTION (2.33 Å)