4X6Y

Human soluble epoxide hydrolase in complex with a cyclopropyl urea derivative

Summary for 4X6Y

• Entry DOI: 10.2210/pdb4x6y/pdb
• Related: 4X6X
• Descriptor: Bifunctional epoxide hydrolase 2, 4-phenoxy-N-[(1S,2R)-2-phenylcyclopropyl]piperidine-1-carboxamide (3 entities in total)
• Functional Keywords: hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 77965.70

Authors

Chiyo, N.,Takai, K.,Ishii, T. (deposition date: 2014-12-09, release date: 2015-04-08, Last modification date: 2023-11-08)

• Primary citation: Takai, K.,Chiyo, N.,Nakajima, T.,Nariai, T.,Ishikawa, C.,Nakatani, S.,Ikeno, A.,Yamamoto, S.,Sone, T.; Three-dimensional rational approach to the discovery of potent substituted cyclopropyl urea soluble epoxide hydrolase inhibitors.; Bioorg.Med.Chem.Lett., 25:1705-1708, 2015; PubMed: 25800114; DOI: 10.1016/j.bmcl.2015.02.076

Experimental method