4X5X

HLA-DR1 mutant bN82A with covalently linked CLIP106-120(M107W)

Summary for 4X5X

Entry DOI	10.2210/pdb4x5x/pdb
Descriptor	HLA class II histocompatibility antigen, DR alpha chain, HLA class II histocompatibility antigen, DRB1-1 beta chain (2 entities in total)
Functional Keywords	mhc ii, immune system, self antigen, invariant chain, clip
Biological source	Homo sapiens (Human) More
Cellular location	Cell membrane; Single-pass type I membrane protein: P01903 P04229
Total number of polymer chains	4
Total formula weight	96230.23
Authors	Guenther, S.,Freund, C. (deposition date: 2014-12-06, release date: 2016-03-09, Last modification date: 2024-01-10)
Primary citation	Wieczorek, M.,Sticht, J.,Stolzenberg, S.,Gunther, S.,Wehmeyer, C.,El Habre, Z.,Alvaro-Benito, M.,Noe, F.,Freund, C. MHC class II complexes sample intermediate states along the peptide exchange pathway. Nat Commun, 7:13224-13224, 2016 Cited by PubMed: 27827392 DOI: 10.1038/ncomms13224 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.199 Å)

Structure validation