4X53

Structure of the class D Beta-Lactamase OXA-160 V130D in Acyl-Enzyme Complex with Aztreonam

Summary for 4X53

• Entry DOI: 10.2210/pdb4x53/pdb
• Related: 4X55 4X56
• Descriptor: Class D beta-lactamase OXA-160, 2-({[(1Z)-1-(2-amino-1,3-thiazol-4-yl)-2-oxo-2-{[(2S,3S)-1-oxo-3-(sulfoamino)butan-2-yl]amino}ethylidene]amino}oxy)-2-methylpropanoic acid, BICARBONATE ION, ... (4 entities in total)
• Functional Keywords: hydrolase, carbapenemase, antibiotic
• Biological source: Acinetobacter baumannii
• Total number of polymer chains: 1
• Total formula weight: 28179.24

Authors

Clasman, J.R.,June, C.M.,Powers, R.A.,Leonard, D.A. (deposition date: 2014-12-04, release date: 2015-03-11, Last modification date: 2023-09-27)

• Primary citation: Mitchell, J.M.,Clasman, J.R.,June, C.M.,Kaitany, K.C.,LaFleur, J.R.,Taracila, M.A.,Klinger, N.V.,Bonomo, R.A.,Wymore, T.,Szarecka, A.,Powers, R.A.,Leonard, D.A.; Structural Basis of Activity against Aztreonam and Extended Spectrum Cephalosporins for Two Carbapenem-Hydrolyzing Class D beta-Lactamases from Acinetobacter baumannii.; Biochemistry, 54:1976-1987, 2015; PubMed: 25710192; DOI: 10.1021/bi501547k

Experimental method

X-RAY DIFFRACTION (2.3 Å)