4X4X

Retrofitting antibodies with stabilizing mutations. Herceptin scFv mutant.

Summary for 4X4X

• Entry DOI: 10.2210/pdb4x4x/pdb
• Related: 4X4Y 4X4Z
• Descriptor: Human Variable Heavy Chain of Herceptin, Human Variable Light Chain of Herceptin (3 entities in total)
• Functional Keywords: antibody stabilization mutations, immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 4
• Total formula weight: 52600.02

Authors

Langley, D.B.,Roome, B.,Christ, D. (deposition date: 2014-12-04, release date: 2015-12-23, Last modification date: 2020-01-08)

• Primary citation: Langley, D.B.,Roome, B.,Christ, D.; Retrofitting antibodies with stabilizing mutations; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.25 Å)