4X2K

Selection of fragments for kinase inhibitor design: decoration is key

Summary for 4X2K

Entry DOI	10.2210/pdb4x2k/pdb
Descriptor	TGF-beta receptor type-1, 4-[(3-aminophenyl)amino]pyrido[2,3-d]pyrimidin-5(6H)-one, SULFATE ION, ... (4 entities in total)
Functional Keywords	transferase, protein kinase, inhibitor complex
Biological source	Homo sapiens (Human)
Cellular location	Cell membrane; Single-pass type I membrane protein: P36897
Total number of polymer chains	1
Total formula weight	35231.47
Authors	Czodrowski, P.,Hoelzemann, G.,Barnickel, G.,Greiner, H.,Musil, D. (deposition date: 2014-11-26, release date: 2014-12-24, Last modification date: 2015-01-21)
Primary citation	Czodrowski, P.,Holzemann, G.,Barnickel, G.,Greiner, H.,Musil, D. Selection of fragments for kinase inhibitor design: decoration is key. J.Med.Chem., 58:457-465, 2015 Cited by PubMed: 25437144 DOI: 10.1021/jm501597j PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.69 Å)

Structure validation