4X1Y
Discovery of cytotoxic Dolastatin 10 analogs with N-terminal modifications
Summary for 4X1Y
Entry DOI | 10.2210/pdb4x1y/pdb |
Related | 4X1I 4X1K 4X20 |
Related PRD ID | PRD_002154 |
Descriptor | Tubulin alpha chain, Tubulin beta chain, Stathmin-4, ... (8 entities in total) |
Functional Keywords | binding sites, competitive, cattle, tumor, colchicine, humans, microtubules, protein binding, protein conformation, protein multimerization, tubulin, tubulin modulators, structural protein-inhibitor complex, structural protein/inhibitor |
Biological source | Rattus norvegicus (Rat) More |
Cellular location | Cytoplasm, cytoskeleton : D0VWY9 Golgi apparatus : P63043 |
Total number of polymer chains | 5 |
Total formula weight | 221252.53 |
Authors | Parris, K.D. (deposition date: 2014-11-25, release date: 2015-03-25, Last modification date: 2023-09-27) |
Primary citation | Maderna, A.,Doroski, M.,Subramanyam, C.,Porte, A.,Leverett, C.A.,Vetelino, B.C.,Chen, Z.,Risley, H.,Parris, K.,Pandit, J.,Varghese, A.H.,Shanker, S.,Song, C.,Sukuru, S.C.,Farley, K.A.,Wagenaar, M.M.,Shapiro, M.J.,Musto, S.,Lam, M.H.,Loganzo, F.,O'Donnell, C.J. Discovery of cytotoxic dolastatin 10 analogues with N-terminal modifications. J.Med.Chem., 57:10527-10543, 2014 Cited by PubMed: 25431858DOI: 10.1021/jm501649k PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.19 Å) |
Structure validation
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