4WZM

Mutant K18E of RNA dependent RNA polymerase from Foot-and-Mouth Disease Virus complexed with RNA

Summary for 4WZM

• Entry DOI: 10.2210/pdb4wzm/pdb
• Related: 1U09 1WNE
• Descriptor: RNA dependent RNA polymerase, RNA template, RNA primer, ... (7 entities in total)
• Functional Keywords: picornavirus, nuclear localization signal, transferase
• Biological source: Foot-and-mouth disease virus (FMDV); More
• Cellular location: Protein VP2: Virion. Protein VP3: Virion. Protein VP1: Virion. Protein 2B: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 2C: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 3A: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 3B-1: Virion . Protein 3B-2: Virion . Protein 3B-3: Virion . Picornain 3C: Host cytoplasm . RNA-directed RNA polymerase 3D-POL: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side : P03311
• Total number of polymer chains: 3
• Total formula weight: 59162.39

Authors

Verdaguer, N.,Ferrer-Orta, C.,de la Higuera, N. (deposition date: 2014-11-20, release date: 2015-05-06, Last modification date: 2024-01-10)

• Primary citation: Ferrer-Orta, C.,de la Higuera, I.,Caridi, F.,Sanchez-Aparicio, M.T.,Moreno, E.,Perales, C.,Singh, K.,Sarafianos, S.G.,Sobrino, F.,Domingo, E.,Verdaguer, N.; Multifunctionality of a picornavirus polymerase domain: nuclear localization signal and nucleotide recognition.; J.Virol., 89:6848-6859, 2015; PubMed: 25903341; DOI: 10.1128/JVI.03283-14

Experimental method

X-RAY DIFFRACTION (2.52 Å)