4WZ8
Crystal structure of human-yeast chimera acetyl coA carboxylase CT domain bound to Compound 6
Summary for 4WZ8
Entry DOI | 10.2210/pdb4wz8/pdb |
Related | 4WYO |
Descriptor | Acetyl-CoA carboxylase, 1'-(2H-indazol-5-ylcarbonyl)-1-(propan-2-yl)-1,4-dihydrospiro[indazole-5,4'-piperidin]-7(6H)-one (3 entities in total) |
Functional Keywords | acc, acetyl-coa, ligase-ligase inhibitor complex, ligase/ligase inhibitor |
Biological source | Saccharomyces cerevisiae (Baker's yeast) |
Cellular location | Cytoplasm: Q00955 |
Total number of polymer chains | 2 |
Total formula weight | 175224.62 |
Authors | Vajdos, F.F. (deposition date: 2014-11-18, release date: 2014-12-10, Last modification date: 2024-02-28) |
Primary citation | Griffith, D.A.,Kung, D.W.,Esler, W.P.,Amor, P.A.,Bagley, S.W.,Beysen, C.,Carvajal-Gonzalez, S.,Doran, S.D.,Limberakis, C.,Mathiowetz, A.M.,McPherson, K.,Price, D.A.,Ravussin, E.,Sonnenberg, G.E.,Southers, J.A.,Sweet, L.J.,Turner, S.M.,Vajdos, F.F. Decreasing the Rate of Metabolic Ketone Reduction in the Discovery of a Clinical Acetyl-CoA Carboxylase Inhibitor for the Treatment of Diabetes. J.Med.Chem., 57:10512-10526, 2014 Cited by PubMed: 25423286DOI: 10.1021/jm5016022 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.23 Å) |
Structure validation
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