4WZ6

Human CFTR aa389-678 (NBD1), deltaF508 with three solubilizing mutations, bound ATP

4WZ6 の概要

• エントリーDOI: 10.2210/pdb4wz6/pdb
• 分子名称: Cystic fibrosis transmembrane conductance regulator, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... (4 entities in total)
• 機能のキーワード: atpase, hydrolase, atp/adp binding, atp binding protein
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Apical cell membrane ; Multi-pass membrane protein {ECO:0000269|Ref: P13569
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 32915.24

構造登録者

Byrnes, L.J.,Hall, J. (登録日: 2014-11-18, 公開日: 2015-11-11, 最終更新日: 2023-09-27)

• 主引用文献: Hall, J.D.,Wang, H.,Byrnes, L.J.,Shanker, S.,Wang, K.,Efremov, I.V.,Chong, P.A.,Forman-Kay, J.D.,Aulabaugh, A.E.; Binding screen for cystic fibrosis transmembrane conductance regulator correctors finds new chemical matter and yields insights into cystic fibrosis therapeutic strategy.; Protein Sci., 25:360-373, 2016; PubMed: 26444971; DOI: 10.1002/pro.2821

実験手法

X-RAY DIFFRACTION (2.05 Å)