4WYL
Mutant K18E of 3D polymerase from Foot-and-Moth Disease Virus
Summary for 4WYL
| Entry DOI | 10.2210/pdb4wyl/pdb |
| Related | 1U09 1WNE |
| Descriptor | RNA-directed RNA polymerase 3D-POL, GLYCEROL, ACETATE ION, ... (5 entities in total) |
| Functional Keywords | closed-right hand rna dependent rna polymerase, transferase |
| Biological source | Foot-and-mouth disease virus (FMDV) |
| Cellular location | Protein VP2: Virion. Protein VP3: Virion. Protein VP1: Virion. Protein 2B: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 2C: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 3A: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 3B-1: Virion . Protein 3B-2: Virion . Protein 3B-3: Virion . Picornain 3C: Host cytoplasm . RNA-directed RNA polymerase 3D-POL: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side : P03311 |
| Total number of polymer chains | 1 |
| Total formula weight | 54567.60 |
| Authors | Ferrer-Orta, C.,Verdaguer, N.,de la Higuera, I.,Domingo, E. (deposition date: 2014-11-17, release date: 2015-05-06, Last modification date: 2024-05-08) |
| Primary citation | Ferrer-Orta, C.,de la Higuera, I.,Caridi, F.,Sanchez-Aparicio, M.T.,Moreno, E.,Perales, C.,Singh, K.,Sarafianos, S.G.,Sobrino, F.,Domingo, E.,Verdaguer, N. Multifunctionality of a picornavirus polymerase domain: nuclear localization signal and nucleotide recognition. J.Virol., 89:6848-6859, 2015 Cited by PubMed: 25903341DOI: 10.1128/JVI.03283-14 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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