4WYL

Mutant K18E of 3D polymerase from Foot-and-Moth Disease Virus

4WYL の概要

• エントリーDOI: 10.2210/pdb4wyl/pdb
• 関連するPDBエントリー: 1U09 1WNE
• 分子名称: RNA-directed RNA polymerase 3D-POL, GLYCEROL, ACETATE ION, ... (5 entities in total)
• 機能のキーワード: closed-right hand rna dependent rna polymerase, transferase
• 由来する生物種: Foot-and-mouth disease virus (FMDV)
• 細胞内の位置: Protein VP2: Virion. Protein VP3: Virion. Protein VP1: Virion. Protein 2B: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 2C: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 3A: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 3B-1: Virion . Protein 3B-2: Virion . Protein 3B-3: Virion . Picornain 3C: Host cytoplasm . RNA-directed RNA polymerase 3D-POL: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side : P03311
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 54567.60

構造登録者

Ferrer-Orta, C.,Verdaguer, N.,de la Higuera, I.,Domingo, E. (登録日: 2014-11-17, 公開日: 2015-05-06, 最終更新日: 2024-05-08)

• 主引用文献: Ferrer-Orta, C.,de la Higuera, I.,Caridi, F.,Sanchez-Aparicio, M.T.,Moreno, E.,Perales, C.,Singh, K.,Sarafianos, S.G.,Sobrino, F.,Domingo, E.,Verdaguer, N.; Multifunctionality of a picornavirus polymerase domain: nuclear localization signal and nucleotide recognition.; J.Virol., 89:6848-6859, 2015; PubMed: 25903341; DOI: 10.1128/JVI.03283-14

実験手法

X-RAY DIFFRACTION (2 Å)