4WYE
Crystal structure of 7,8-diaminopelargonic acid synthase (BioA) from Mycobacterium tuberculosis complexed with a DSF fragment hit
Summary for 4WYE
| Entry DOI | 10.2210/pdb4wye/pdb |
| Related | 4WYA 4WYC 4WYD 4WYF 4WYG |
| Descriptor | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase, PYRIDOXAL-5'-PHOSPHATE, phenyl(piperidin-4-yl)methanone, ... (7 entities in total) |
| Functional Keywords | complex, transaminase, plp, fragment, transferase/transferase inhibitor, transferase-transferase inhibitor complex |
| Biological source | Mycobacterium tuberculosis |
| Cellular location | Cytoplasm : P9WQ81 |
| Total number of polymer chains | 2 |
| Total formula weight | 98576.58 |
| Authors | Dai, R.,Finzel, B.C. (deposition date: 2014-11-17, release date: 2015-07-08, Last modification date: 2015-07-22) |
| Primary citation | Dai, R.,Geders, T.W.,Liu, F.,Park, S.W.,Schnappinger, D.,Aldrich, C.C.,Finzel, B.C. Fragment-Based Exploration of Binding Site Flexibility in Mycobacterium tuberculosis BioA. J.Med.Chem., 58:5208-5217, 2015 Cited by PubMed: 26068403DOI: 10.1021/acs.jmedchem.5b00092 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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