4WYA

Crystal structure of 7,8-diaminopelargonic acid synthase (BioA) from Mycobacterium tuberculosis, complexed with a fragment hit

Summary for 4WYA

Entry DOI	10.2210/pdb4wya/pdb
Related	4WYC 4WYD 4WYE 4WYF 4WYG
Descriptor	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase, PYRIDOXAL-5'-PHOSPHATE, 5-(pyridin-2-yl)thiophene-2-carboxamide, ... (4 entities in total)
Functional Keywords	inhibitor complex transaminase plp, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Cellular location	Cytoplasm : P9WQ81
Total number of polymer chains	4
Total formula weight	195543.14
Authors	Finzel, B.C.,Dai, D.,Geders, T.W. (deposition date: 2014-11-17, release date: 2015-07-15, Last modification date: 2023-09-27)
Primary citation	Dai, R.,Geders, T.W.,Liu, F.,Park, S.W.,Schnappinger, D.,Aldrich, C.C.,Finzel, B.C. Fragment-Based Exploration of Binding Site Flexibility in Mycobacterium tuberculosis BioA. J.Med.Chem., 58:5208-5217, 2015 Cited by PubMed: 26068403 DOI: 10.1021/acs.jmedchem.5b00092 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation