4WXQ

Crystal Structure of the Myocilin Olfactomedin Domain

Summary for 4WXQ

• Entry DOI: 10.2210/pdb4wxq/pdb
• Related: 4WXS 4WXU
• Descriptor: Myocilin, CALCIUM ION, HEXAETHYLENE GLYCOL, ... (5 entities in total)
• Functional Keywords: beta propeller, 5 bladed propeller, olfactomedin, protein binding
• Biological source: Homo sapiens (Human)
• Cellular location: Secreted . Myocilin, C-terminal fragment: Secreted. Myocilin, N-terminal fragment: Endoplasmic reticulum: Q99972
• Total number of polymer chains: 1
• Total formula weight: 33236.36

Authors

Orwig, S.D.,Turnage, K.C.,Donegan, R.K.,Lieberman, R.L. (deposition date: 2014-11-14, release date: 2015-04-01, Last modification date: 2017-09-06)

• Primary citation: Donegan, R.K.,Hill, S.E.,Freeman, D.M.,Nguyen, E.,Orwig, S.D.,Turnage, K.C.,Lieberman, R.L.; Structural basis for misfolding in myocilin-associated glaucoma.; Hum.Mol.Genet., 24:2111-2124, 2015; PubMed: 25524706; DOI: 10.1093/hmg/ddu730

Experimental method

X-RAY DIFFRACTION (2.15 Å)