4WX4

Crystal structure of adenovirus 8 protease in complex with a nitrile inhibitor

4WX4 の概要

• エントリーDOI: 10.2210/pdb4wx4/pdb
• 分子名称: Protease, peptide, N-[(2-cyanopyrimidin-4-yl)methyl]-3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-4-methoxybenzamide, ... (6 entities in total)
• 機能のキーワード: cysteine protease, inhibitor, cofactor, hydrolase
• 由来する生物種: Human adenovirus D serotype 8 (HAdV-8); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 25234.87

構造登録者

Grosche, P.,Sirockin, F.,Mac Sweeney, A.,Ramage, P.,Erbel, P.,Melkko, S.,Bernardi, A.,Hughes, N.,Ellis, D.,Combrink, K.,Jarousse, N.,Altmann, E. (登録日: 2014-11-13, 公開日: 2015-01-14, 最終更新日: 2015-01-28)

• 主引用文献: Grosche, P.,Sirockin, F.,Mac Sweeney, A.,Ramage, P.,Erbel, P.,Melkko, S.,Bernardi, A.,Hughes, N.,Ellis, D.,Combrink, K.D.,Jarousse, N.,Altmann, E.; Structure-based design and optimization of potent inhibitors of the adenoviral protease.; Bioorg.Med.Chem.Lett., 25:438-443, 2015; PubMed: 25571794; DOI: 10.1016/j.bmcl.2014.12.057

実験手法

X-RAY DIFFRACTION (1.03 Å)