4WVT

Crystal structure of XIAP-BIR2 domain complexed with ligand bound

Summary for 4WVT

• Entry DOI: 10.2210/pdb4wvt/pdb
• Related: 4wvs 4wvu
• Related PRD ID: PRD_002133
• Descriptor: E3 ubiquitin-protein ligase XIAP, 3,11-DIFLUORO-6,8,13-TRIMETHYL-8H-QUINO[4,3,2-KL]ACRIDIN-13-IUM, ZINC ION, ... (4 entities in total)
• Functional Keywords: iap, xiap-bir2, apoptosis
• Biological source: Homo sapiens (Human); More
• Cellular location: Cytoplasm: P98170
• Total number of polymer chains: 4
• Total formula weight: 24411.94

Authors

Pokross, M.E. (deposition date: 2014-11-07, release date: 2015-03-04, Last modification date: 2015-04-08)

• Primary citation: Seigal, B.A.,Connors, W.H.,Fraley, A.,Borzilleri, R.M.,Carter, P.H.,Emanuel, S.L.,Fargnoli, J.,Kim, K.,Lei, M.,Naglich, J.G.,Pokross, M.E.,Posy, S.L.,Shen, H.,Surti, N.,Talbott, R.,Zhang, Y.,Terrett, N.K.; The Discovery of Macrocyclic XIAP Antagonists from a DNA-Programmed Chemistry Library, and Their Optimization To Give Lead Compounds with in Vivo Antitumor Activity.; J.Med.Chem., 58:2855-2861, 2015; PubMed: 25695766; DOI: 10.1021/jm501892g

Experimental method

X-RAY DIFFRACTION (1.96 Å)