4WVD

Identification of a novel FXR ligand that regulates metabolism

「4II6」から置き換えられました

4WVD の概要

• エントリーDOI: 10.2210/pdb4wvd/pdb
• 分子名称: Nuclear receptor corepressor 1, Bile acid receptor, FORMIC ACID, ... (5 entities in total)
• 機能のキーワード: af-2 helix, ligand binding pocket, three-layer helical sandwich, transcription regulator fxr, bar, nr1h4, bile acid receptor, nhr, nuclear receptor, corepressor, transcription, transcription regulation
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Nucleus : O75376; Nucleus . Isoform 1: Nucleus . Isoform 2: Nucleus . Isoform 3: Nucleus . Isoform 4: Nucleus : Q96RI1
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 55059.29

構造登録者

Wang, R.,Li, Y. (登録日: 2014-11-05, 公開日: 2015-02-11, 最終更新日: 2024-03-20)

• 主引用文献: Jin, L.,Feng, X.,Rong, H.,Pan, Z.,Inaba, Y.,Qiu, L.,Zheng, W.,Lin, S.,Wang, R.,Wang, Z.,Wang, S.,Liu, H.,Li, S.,Xie, W.,Li, Y.; The antiparasitic drug ivermectin is a novel FXR ligand that regulates metabolism.; Nat Commun, 4:1937-, 2013; PubMed: 23728580; DOI: 10.1038/ncomms2924

実験手法

X-RAY DIFFRACTION (2.9 Å)