4WV5
HEAT SHOCK PROTEIN 70 SUBSTRATE BINDING DOMAIN
Summary for 4WV5
Entry DOI | 10.2210/pdb4wv5/pdb |
Related | 4WV7 |
Descriptor | Heat shock 70 kDa protein 1A/1B, GLYCEROL (3 entities in total) |
Functional Keywords | chaperone |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : P08107 |
Total number of polymer chains | 2 |
Total formula weight | 33059.13 |
Authors | |
Primary citation | Hassan, A.Q.,Kirby, C.A.,Zhou, W.,Schuhmann, T.,Kityk, R.,Kipp, D.R.,Baird, J.,Chen, J.,Chen, Y.,Chung, F.,Hoepfner, D.,Movva, N.R.,Pagliarini, R.,Petersen, F.,Quinn, C.,Quinn, D.,Riedl, R.,Schmitt, E.K.,Schitter, A.,Stams, T.,Studer, C.,Fortin, P.D.,Mayer, M.P.,Sadlish, H. The novolactone natural product disrupts the allosteric regulation of hsp70. Chem.Biol., 22:87-97, 2015 Cited by PubMed: 25544045DOI: 10.1016/j.chembiol.2014.11.007 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.04 Å) |
Structure validation
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