4WV1
Crystal structure of the FGFR2 D2 domain in complex with Fab 2B.1.3
Summary for 4WV1
Entry DOI | 10.2210/pdb4wv1/pdb |
Descriptor | Fibroblast growth factor receptor 2, Fab heavy chain, Fab light chain, ... (4 entities in total) |
Functional Keywords | fgfr2, fab, complex, antibody, transferase-immune system complex, transferase/immune system |
Biological source | Homo sapiens (Human) More |
Cellular location | Cell membrane; Single-pass type I membrane protein. Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 3: Cell membrane; Single-pass type I membrane protein. Isoform 14: Secreted. Isoform 19: Secreted: P21802 |
Total number of polymer chains | 6 |
Total formula weight | 118294.05 |
Authors | Yin, Y.,Carter, P.J. (deposition date: 2014-11-04, release date: 2015-09-16, Last modification date: 2023-09-27) |
Primary citation | Yin, Y.,Djakovic, S.,Marsters, S.,Tien, J.,Peng, J.,Tremayne, J.,Lee, G.,Neve, R.M.,Wu, Y.,Merchant, M.,Ashkenazi, A.,Carter, P.J. Redesigning a Monospecific Anti-FGFR3 Antibody to Add Selectivity for FGFR2 and Expand Antitumor Activity. Mol.Cancer Ther., 14:2270-2278, 2015 Cited by PubMed: 26269606DOI: 10.1158/1535-7163.MCT-14-1050 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.362 Å) |
Structure validation
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