4WTB

BthTX-I, a svPLA2s-like toxin, complexed with zinc ions

Summary for 4WTB

• Entry DOI: 10.2210/pdb4wtb/pdb
• Related: 3HZW 3I03 3I3H 3IQ3 3QNL
• Descriptor: Basic phospholipase A2 homolog bothropstoxin-1, ZINC ION, SULFATE ION, ... (5 entities in total)
• Functional Keywords: svpla2-like inhibitor, bthtx-i, toxin
• Biological source: Bothrops jararacussu (Jararacussu)
• Total number of polymer chains: 2
• Total formula weight: 27933.48

Authors

Borges, R.J.,Fontes, M.R.M. (deposition date: 2014-10-29, release date: 2015-11-11, Last modification date: 2024-11-13)

Primary citation

Borges, R.J.,Cardoso, F.F.,Fernandes, C.A.,Dreyer, T.R.,de Moraes, D.S.,Floriano, R.S.,Rodrigues-Simioni, L.,Fontes, M.R.
Functional and structural studies of a Phospholipase A2-like protein complexed to zinc ions: Insights on its myotoxicity and inhibition mechanism.
Biochim. Biophys. Acta, 1861:3199-3209, 2017

PubMed Abstract: One of the main challenges in snakebite envenomation treatment is the development of stable, versatile and efficient anti-venom therapies. Local myotoxicity in accidents involving snakes from the Bothrops genus is still a consequence of serum therapy inefficient neutralization that may lead to permanent sequelae in their victims. One of the classes of toxins that participate in muscle necrosis is the PLA-like proteins. The aim of this work was to investigate the role of zinc ions in the inhibition of PLA-like proteins and to advance the current knowledge of their action mechanism.

PubMed: 27531710
DOI: 10.1016/j.bbagen.2016.08.003

Experimental method

X-RAY DIFFRACTION (2.16 Å)