4WTB

BthTX-I, a svPLA2s-like toxin, complexed with zinc ions

4WTB の概要

• エントリーDOI: 10.2210/pdb4wtb/pdb
• 関連するPDBエントリー: 3HZW 3I03 3I3H 3IQ3 3QNL
• 分子名称: Basic phospholipase A2 homolog bothropstoxin-1, ZINC ION, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: svpla2-like inhibitor, bthtx-i, toxin
• 由来する生物種: Bothrops jararacussu (Jararacussu)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 27933.48

構造登録者

Borges, R.J.,Fontes, M.R.M. (登録日: 2014-10-29, 公開日: 2015-11-11, 最終更新日: 2024-11-13)

主引用文献

Borges, R.J.,Cardoso, F.F.,Fernandes, C.A.,Dreyer, T.R.,de Moraes, D.S.,Floriano, R.S.,Rodrigues-Simioni, L.,Fontes, M.R.
Functional and structural studies of a Phospholipase A2-like protein complexed to zinc ions: Insights on its myotoxicity and inhibition mechanism.
Biochim. Biophys. Acta, 1861:3199-3209, 2017

PubMed Abstract: One of the main challenges in snakebite envenomation treatment is the development of stable, versatile and efficient anti-venom therapies. Local myotoxicity in accidents involving snakes from the Bothrops genus is still a consequence of serum therapy inefficient neutralization that may lead to permanent sequelae in their victims. One of the classes of toxins that participate in muscle necrosis is the PLA-like proteins. The aim of this work was to investigate the role of zinc ions in the inhibition of PLA-like proteins and to advance the current knowledge of their action mechanism.

PubMed: 27531710
DOI: 10.1016/j.bbagen.2016.08.003

実験手法

X-RAY DIFFRACTION (2.16 Å)