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4WT2

Co-crystal Structure of MDM2 in Complex with AM-7209

Summary for 4WT2
Entry DOI10.2210/pdb4wt2/pdb
DescriptorE3 ubiquitin-protein ligase Mdm2, 4-({[(3R,5R,6S)-1-[(1S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl]-6-(4-chloro-3-fluorophenyl)-5-(3-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]acetyl}amino)-2-methoxybenzoic acid, SULFATE ION, ... (4 entities in total)
Functional Keywordsp53, protein-protein interaction, ligase-ligase inhibitor complex, ligase/ligase inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationNucleus, nucleoplasm: Q00987
Total number of polymer chains1
Total formula weight12984.90
Authors
Shaffer, P.L.,Huang, X.,Yakowec, P.,Long, A.M. (deposition date: 2014-10-30, release date: 2014-12-03, Last modification date: 2023-09-27)
Primary citationRew, Y.,Sun, D.,Yan, X.,Beck, H.P.,Canon, J.,Chen, A.,Duquette, J.,Eksterowicz, J.,Fox, B.M.,Fu, J.,Gonzalez, A.Z.,Houze, J.,Huang, X.,Jiang, M.,Jin, L.,Li, Y.,Li, Z.,Ling, Y.,Lo, M.C.,Long, A.M.,McGee, L.R.,McIntosh, J.,Oliner, J.D.,Osgood, T.,Saiki, A.Y.,Shaffer, P.,Wang, Y.C.,Wortman, S.,Yakowec, P.,Ye, Q.,Yu, D.,Zhao, X.,Zhou, J.,Medina, J.C.,Olson, S.H.
Discovery of AM-7209, a Potent and Selective 4-Amidobenzoic Acid Inhibitor of the MDM2-p53 Interaction.
J.Med.Chem., 57:10499-10511, 2014
Cited by
PubMed: 25384157
DOI: 10.1021/jm501550p
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.42 Å)
Structure validation

217705

건을2024-03-27부터공개중

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