4WT2

Co-crystal Structure of MDM2 in Complex with AM-7209

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0043066	biological_process	negative regulation of apoptotic process
A	0051726	biological_process	regulation of cell cycle

Functional Information from PDB Data

site_id	AC1
Number of Residues	20
Details	binding site for residue 3UD A 201

Chain	Residue
A	MET6
A	VAL93
A	LYS94
A	HIS96
A	ILE99
A	VAL109
A	VAL110
A	HOH325
A	HOH327
A	HOH329
A	HOH340
A	VAL14
A	HOH413
A	THR16
A	GLN18
A	GLU23
A	LEU54
A	ILE61
A	MET62
A	PHE91

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site_id	AC2
Number of Residues	6
Details	binding site for residue SO4 A 202

Chain	Residue
A	MET6
A	SER7
A	THR16
A	SER17
A	HOH347
A	HOH381

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site_id	AC3
Number of Residues	7
Details	binding site for residue SO4 A 203

Chain	Residue
A	PRO20
A	ALA21
A	THR63
A	HOH317
A	HOH331
A	HOH373
A	HOH402

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