4WQP

Crystal structure of RORc in complex with a benzyl sulfonamide inverse agonist

Summary for 4WQP

• Entry DOI: 10.2210/pdb4wqp/pdb
• Descriptor: Nuclear receptor ROR-gamma, VAL-GLU-ARG-LEU-GLN-ILE-PHE-GLN-HIS-LEU-HIS-PRO-ILE, N-[4-(4-acetylpiperazin-1-yl)benzyl]-N-(2-methylpropyl)-1-phenylmethanesulfonamide, ... (5 entities in total)
• Functional Keywords: nuclear receptor ligand binding domain, transcription
• Biological source: Homo sapiens (Human); More
• Cellular location: Nucleus : P51449
• Total number of polymer chains: 3
• Total formula weight: 64419.26

Authors

Boenig, G.,Hymowitz, S.G. (deposition date: 2014-10-22, release date: 2015-01-14, Last modification date: 2023-12-27)

• Primary citation: Rene, O.,Fauber, B.P.,de Leon Boenig, G.,Burton, B.,Eidenschenk, C.,Everett, C.,Gobbi, A.,Hymowitz, S.G.,Johnson, A.R.,Kiefer, J.R.,Liimatta, M.,Lockey, P.,Norman, M.,Ouyang, W.,Wallweber, H.A.,Wong, H.; Minor Structural Change to Tertiary Sulfonamide RORc Ligands Led to Opposite Mechanisms of Action.; Acs Med.Chem.Lett., 6:276-281, 2015; PubMed: 25815138; DOI: 10.1021/ml500420y

Experimental method

X-RAY DIFFRACTION (1.99 Å)