4WQ3

Human calpain PEF(S) with (2Z,2Z')-2,2'-disulfanediylbis(3-(6-bromoindol-3-yl)acrylic acid) bound

Summary for 4WQ3

Entry DOI	10.2210/pdb4wq3/pdb
Descriptor	Calpain small subunit 1, CALCIUM ION, (2Z)-3-(6-bromo-1H-indol-3-yl)-2-sulfanylprop-2-enoic acid, ... (4 entities in total)
Functional Keywords	pef(s), domain vi, calcium binding domain, cysteine protease, mercaptoacrylic acid, hydrolase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm : P04632
Total number of polymer chains	2
Total formula weight	41546.46
Authors	Adams, S.E.,Robinson, E.J.,Rizkallah, P.J.,Miller, D.J.,Hallett, M.B.,Allemann, R.K. (deposition date: 2014-10-21, release date: 2015-09-02, Last modification date: 2024-01-10)
Primary citation	Adams, S.E.,Robinson, E.J.,Miller, D.J.,Rizkallah, P.J.,Hallett, M.B.,Allemann, R.K. Conformationally restricted calpain inhibitors. Chem Sci, 6:6865-6871, 2015 Cited by PubMed: 28757975 DOI: 10.1039/c5sc01158b PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.79 Å)

Structure validation