4WQ3
Human calpain PEF(S) with (2Z,2Z')-2,2'-disulfanediylbis(3-(6-bromoindol-3-yl)acrylic acid) bound
Summary for 4WQ3
Entry DOI | 10.2210/pdb4wq3/pdb |
Descriptor | Calpain small subunit 1, CALCIUM ION, (2Z)-3-(6-bromo-1H-indol-3-yl)-2-sulfanylprop-2-enoic acid, ... (4 entities in total) |
Functional Keywords | pef(s), domain vi, calcium binding domain, cysteine protease, mercaptoacrylic acid, hydrolase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : P04632 |
Total number of polymer chains | 2 |
Total formula weight | 41546.46 |
Authors | Adams, S.E.,Robinson, E.J.,Rizkallah, P.J.,Miller, D.J.,Hallett, M.B.,Allemann, R.K. (deposition date: 2014-10-21, release date: 2015-09-02, Last modification date: 2024-01-10) |
Primary citation | Adams, S.E.,Robinson, E.J.,Miller, D.J.,Rizkallah, P.J.,Hallett, M.B.,Allemann, R.K. Conformationally restricted calpain inhibitors. Chem Sci, 6:6865-6871, 2015 Cited by PubMed: 28757975DOI: 10.1039/c5sc01158b PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.79 Å) |
Structure validation
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