4WOV
CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH BMS-066 AKA 2-METHOXY-N-({6-[3-METHYL-7-(METHYLAMINO)-3,5,8,10-TETRAAZATRICYCLO[7.3.0.0, 6]DODECA-1(9),2(6),4,7,11-PENTAEN-11-YL]PYRIDIN-2-YL}METHY L)ACETAMIDE
4WOV の概要
エントリーDOI | 10.2210/pdb4wov/pdb |
分子名称 | Non-receptor tyrosine-protein kinase TYK2, 2-methoxy-N-({6-[1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl]pyridin-2-yl}methyl)acetamide, SULFATE ION, ... (4 entities in total) |
機能のキーワード | kinase, tyk2, pseudokinase, transferase-inhibitor complex, transferase/inhibitor |
由来する生物種 | Homo sapiens (Human) |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 72237.46 |
構造登録者 | |
主引用文献 | Tokarski, J.S.,Zupa-Fernandez, A.,Tredup, J.A.,Pike, K.,Chang, C.,Xie, D.,Cheng, L.,Pedicord, D.,Muckelbauer, J.,Johnson, S.R.,Wu, S.,Edavettal, S.C.,Hong, Y.,Witmer, M.R.,Elkin, L.L.,Blat, Y.,Pitts, W.J.,Weinstein, D.S.,Burke, J.R. Tyrosine Kinase 2-mediated Signal Transduction in T Lymphocytes Is Blocked by Pharmacological Stabilization of Its Pseudokinase Domain. J.Biol.Chem., 290:11061-11074, 2015 Cited by PubMed: 25762719DOI: 10.1074/jbc.M114.619502 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.8 Å) |
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