4WOT
ROCK2 IN COMPLEX WITH 1426382-07-1
Summary for 4WOT
Entry DOI | 10.2210/pdb4wot/pdb |
Descriptor | Rho-associated protein kinase 2, methyl 3-[({2'-(aminomethyl)-5'-[(3-fluoropyridin-4-yl)carbamoyl]biphenyl-3-yl}carbonyl)amino]-4-fluorobenzoate (3 entities in total) |
Functional Keywords | transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: O75116 |
Total number of polymer chains | 4 |
Total formula weight | 183952.89 |
Authors | Augustin, M.,Krapp, S.,Boland, S.,Defert, O.,Bourin, A.,Alen, J.,Leysen, D. (deposition date: 2014-10-16, release date: 2015-05-06, Last modification date: 2024-05-08) |
Primary citation | Boland, S.,Bourin, A.,Alen, J.,Geraets, J.,Schroeders, P.,Castermans, K.,Kindt, N.,Boumans, N.,Panitti, L.,Fransen, S.,Vanormelingen, J.,Stassen, J.M.,Leysen, D.,Defert, O. Design, synthesis, and biological evaluation of novel, highly active soft ROCK inhibitors. J. Med. Chem., 58:4309-4324, 2015 Cited by PubMed: 25898023DOI: 10.1021/acs.jmedchem.5b00308 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.93 Å) |
Structure validation
Download full validation report