4WNJ
Crystal structure of Transthyretin-quercetin complex
Summary for 4WNJ
Entry DOI | 10.2210/pdb4wnj/pdb |
Descriptor | Transthyretin, DIMETHYL SULFOXIDE, 3,5,7,3',4'-PENTAHYDROXYFLAVONE, ... (4 entities in total) |
Functional Keywords | amyloidosis; protein misfolding, negative cooperativity, fibrillogenesis inhibitors, transthyretin stabilizers, transport protein |
Biological source | Homo sapiens (Human) |
Cellular location | Secreted: P02766 |
Total number of polymer chains | 2 |
Total formula weight | 28013.22 |
Authors | Zanotti, G.,Cianci, M.,Berni, R.,Folli, C. (deposition date: 2014-10-13, release date: 2015-08-05, Last modification date: 2024-01-10) |
Primary citation | Cianci, M.,Folli, C.,Zonta, F.,Florio, P.,Berni, R.,Zanotti, G. Structural evidence for asymmetric ligand binding to transthyretin. Acta Crystallogr.,Sect.D, 71:1582-1592, 2015 Cited by PubMed: 26249340DOI: 10.1107/S1399004715010585 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.398 Å) |
Structure validation
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