4WN1
Crystal structure of PDE10A in complex with 1-methyl-5-(1-methyl-3-{[4-(quinolin-2-yl)phenoxy]methyl}-1H-pyrazol-4-yl)pyridin-2(1H)-one
Summary for 4WN1
Entry DOI | 10.2210/pdb4wn1/pdb |
Descriptor | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, ZINC ION, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | phosphodiesterase, complex, inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: Q9Y233 |
Total number of polymer chains | 2 |
Total formula weight | 79814.77 |
Authors | Amano, Y.,Honbou, K. (deposition date: 2014-10-10, release date: 2014-12-31, Last modification date: 2023-12-27) |
Primary citation | Hamaguchi, W.,Masuda, N.,Miyamoto, S.,Shiina, Y.,Kikuchi, S.,Mihara, T.,Moriguchi, H.,Fushiki, H.,Murakami, Y.,Amano, Y.,Honbou, K.,Hattori, K. Synthesis, SAR study, and biological evaluation of novel quinoline derivatives as phosphodiesterase 10A inhibitors with reduced CYP3A4 inhibition. Bioorg.Med.Chem., 23:297-313, 2015 Cited by PubMed: 25515954DOI: 10.1016/j.bmc.2014.11.039 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.13 Å) |
Structure validation
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