4WMZ

S. cerevisiae CYP51 complexed with fluconazole in the active site

4WMZ の概要

• エントリーDOI: 10.2210/pdb4wmz/pdb
• 関連するPDBエントリー: 4K0F 4LXJ
• 分子名称: Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE, 2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL, ... (4 entities in total)
• 機能のキーワード: fluconazole, cyp51, oxidoreductase-oxidoreducatse inhibitor complex, oxidoreductase/oxidoreducatse inhibitor
• 由来する生物種: Saccharomyces cerevisiae (Baker's yeast)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 62807.97

構造登録者

Sagatova, A.,Keniya, M.V.,Wilson, R.,Wilbanks, S.M.,Monk, B.C.,Tyndall, J.D.A. (登録日: 2014-10-09, 公開日: 2015-07-01, 最終更新日: 2023-09-27)

• 主引用文献: Sagatova, A.A.,Keniya, M.V.,Wilson, R.K.,Monk, B.C.,Tyndall, J.D.; Structural Insights into Binding of the Antifungal Drug Fluconazole to Saccharomyces cerevisiae Lanosterol 14 alpha-Demethylase.; Antimicrob.Agents Chemother., 59:4982-4989, 2015; PubMed: 26055382; DOI: 10.1128/AAC.00925-15

実験手法

X-RAY DIFFRACTION (2.05 Å)