4WMC

OXA-48 covalent complex with Avibactam inhibitor

Summary for 4WMC

• Entry DOI: 10.2210/pdb4wmc/pdb
• Related: 3HBR
• Descriptor: Beta-lactamase, (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, CARBON DIOXIDE, ... (5 entities in total)
• Functional Keywords: oxa-48, class d carbapenemase, avibactam, inhibitor, hydrolase
• Biological source: Klebsiella pneumoniae; More
• Total number of polymer chains: 8
• Total formula weight: 226794.26

Authors

Mangani, S.,Benvenuti, M.,Docquier, J.D. (deposition date: 2014-10-08, release date: 2014-12-03, Last modification date: 2024-01-10)

• Primary citation: Lahiri, S.D.,Mangani, S.,Jahic, H.,Benvenuti, M.,Durand-Reville, T.F.,De Luca, F.,Ehmann, D.E.,Rossolini, G.M.,Alm, R.A.,Docquier, J.D.; Molecular Basis of Selective Inhibition and Slow Reversibility of Avibactam against Class D Carbapenemases: A Structure-Guided Study of OXA-24 and OXA-48.; Acs Chem.Biol., 10:591-600, 2015; PubMed: 25406838; DOI: 10.1021/cb500703p

Experimental method

X-RAY DIFFRACTION (2.3 Å)