4WLB
Crystal structure of RORc in complex with a partial inverse agonist compound
Summary for 4WLB
Entry DOI | 10.2210/pdb4wlb/pdb |
Descriptor | Nuclear receptor ROR-gamma, SRC-1 peptide, N-(4-fluorobenzyl)-N-(2-methylpropyl)-6-{[1-(methylsulfonyl)piperidin-4-yl]amino}pyridine-3-sulfonamide, ... (5 entities in total) |
Functional Keywords | nuclear receptor ligand binding domain, transcription |
Biological source | Homo sapiens (Human) More |
Cellular location | Nucleus : P51449 |
Total number of polymer chains | 4 |
Total formula weight | 64866.79 |
Authors | Boenig, G.,Hymowitz, S.G.,Kiefer, J.R. (deposition date: 2014-10-07, release date: 2014-11-12, Last modification date: 2023-12-27) |
Primary citation | van Niel, M.B.,Fauber, B.P.,Cartwright, M.,Gaines, S.,Killen, J.C.,Rene, O.,Ward, S.I.,de Leon Boenig, G.,Deng, Y.,Eidenschenk, C.,Everett, C.,Gancia, E.,Ganguli, A.,Gobbi, A.,Hawkins, J.,Johnson, A.R.,Kiefer, J.R.,La, H.,Lockey, P.,Norman, M.,Ouyang, W.,Qin, A.,Wakes, N.,Waszkowycz, B.,Wong, H. A reversed sulfonamide series of selective RORc inverse agonists. Bioorg.Med.Chem.Lett., 24:5769-5776, 2014 Cited by PubMed: 25453817DOI: 10.1016/j.bmcl.2014.10.037 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.702 Å) |
Structure validation
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