4WKT

n-Alkylboronic Acid Inhibitors Reveal Determinants of Ligand Specificity in the Quorum-Quenching and Siderophore Biosynthetic Enzyme PvdQ

Summary for 4WKT

• Entry DOI: 10.2210/pdb4wkt/pdb
• Related: 4WKS 4WKU 4WKV
• Descriptor: Acyl-homoserine lactone acylase PvdQ, 1-BUTANE BORONIC ACID, GLYCEROL, ... (5 entities in total)
• Functional Keywords: n-alkylboronic acid inhibitors of pvdq, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Pseudomonas aeruginosa; More
• Cellular location: Periplasm : Q9I194 Q9I194
• Total number of polymer chains: 2
• Total formula weight: 80384.90

Authors

Wu, R.,Clevenger, K.D.,Fast, W.,Liu, D. (deposition date: 2014-10-03, release date: 2014-11-12, Last modification date: 2023-12-27)

• Primary citation: Clevenger, K.D.,Wu, R.,Liu, D.,Fast, W.; n-Alkylboronic Acid Inhibitors Reveal Determinants of Ligand Specificity in the Quorum-Quenching and Siderophore Biosynthetic Enzyme PvdQ.; Biochemistry, 53:6679-6686, 2014; PubMed: 25290020; DOI: 10.1021/bi501086s

Experimental method

X-RAY DIFFRACTION (1.782 Å)