4WK8
FOXP3 forms a domain-swapped dimer to bridge DNA
Summary for 4WK8
Entry DOI | 10.2210/pdb4wk8/pdb |
Descriptor | DNA (5'-D(*TP*TP*AP*GP*GP*AP*AP*AP*AP*TP*TP*TP*GP*TP*TP*TP*CP*AP*TP*AP*G)-3'), DNA (5'-D(*AP*AP*CP*TP*AP*TP*GP*AP*AP*AP*CP*AP*AP*AP*TP*TP*TP*TP*CP*CP*T)-3'), Forkhead box protein P3 (3 entities in total) |
Functional Keywords | foxp3, regulatory t cells, dna bridging, transcription regulation, transcription-dna complex, transcription/dna |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 33045.87 |
Authors | |
Primary citation | Chen, Y.,Chen, C.,Zhang, Z.,Liu, C.C.,Johnson, M.E.,Espinoza, C.A.,Edsall, L.E.,Ren, B.,Zhou, X.J.,Grant, S.F.,Wells, A.D.,Chen, L. DNA binding by FOXP3 domain-swapped dimer suggests mechanisms of long-range chromosomal interactions. Nucleic Acids Res., 43:1268-1282, 2015 Cited by PubMed: 25567984DOI: 10.1093/nar/gku1373 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.4006 Å) |
Structure validation
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